The Ionian Revolt
The Ionians revolted against the Persian rule because the Persians conquered the wealthy Greek settlements in Ionia in Asia Minor. The Persians also toke away the Ionian farmland and harbors, and made them pay taxes to them.
The Ionians knew they couldn't defeat the Persians, so they called the Greece mainlands to come and help. Athens responded to their call. Athens came ready to battle, then they left the Ionians to lose. After losing, the Ionians were punished by the Persians. The Persians burned down Milteus as a punishment for rebelling. They also put some Ionians into slavery.